Endocrine/Metabolic: Instances of serotonin syndrome, a potentially everyday living-threatening issue, have already been reported through concomitant use of opioids with serotonergic medicines.

NMS is a serious problem that can result in death. Halt having promethazine/codeine and connect with your healthcare service provider without delay For those who have any of the following signs or symptoms.

“Numerous Neighborhood pharmacists by now no longer stock codeine linctus on account of fears about addiction and abuse.

Night time Nurse is obtainable from the pharmacy counter. Remember to ask your pharmacist To find out more.

This enzyme breaks codeine down into morphine quicker in a lot of people than in Some others. This may lead to codeine taking outcome extra promptly than envisioned, resulting in a large or an overdose sometimes.

are pregnant or system to be Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Alternative can harm your unborn infant. See “What exactly is The main info I should understand about Promethazine Hydrochloride and Codeine Phosphate Oral Remedy?” are breastfeeding or plan to breastfeed. Codeine passes into your breast milk and could potentially cause critical Uncomfortable side effects inside your newborn more info like increased sleepiness, respiration issues (respiratory despair), and Dying. It's not at all recognized if promethazine can move into your breast milk.

Marketing or giving get more info away Promethazine Hydrochloride and Codeine Phosphate Oral Remedy may well harm Many others, and is particularly versus the law. Inform your healthcare company In case you have ever abused or been dependent on Liquor, prescription medicines or street prescription drugs.

Promethazine is metabolized from the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing during the urine.

Subsequently, and making an allowance for the reports we have received in relation to abuse, we have reclassified codeine linctus to some prescription-only medication for the good thing about sufferers, carers and Health care gurus through the United kingdom.

President Professor Claire Anderson reported: “This determination not only addresses issues with Akorn Promethazine with codeine syrup regards to the misuse and addictive possible of codeine linctus and also underscores the necessity of prioritising affected person well-remaining.

Codeine: Dosage of codeine SHOULD NOT BE Elevated if cough fails to respond; an unresponsive cough needs to be reevaluated in 5 days or quicker for probable underlying pathology, like foreign system or decrease respiratory tract disorder.

Ensure that sufferers have an oral dosing dispenser that actions the right quantity in milliliters. Counsel individuals on how to benefit from an oral dosing dispenser and correctly measure the oral suspension as prescribed.

For prescriptions click here exactly where a measuring product isn't delivered, a pharmacist can provide an acceptable calibrated measuring device and can provide Recommendations for measuring the correct check here dose.

長期使用時，身體可對可待因產生耐藥性，令藥效減弱，並有可能產生依賴性。